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 Posted By:   Healthprior21

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 In a first-of-its-kind operation in the United States, a team of doctors at Duke University Hospital helped create a bioengineered blood vessel.

 

The new vein is different from other implanted innovations in that it is human cell-based with no biological properties that would cause organ rejection.

 

The tissue of this artificially grown blood vessel is made from donated human cells. These cells are placed in a solution of amino acids, vitamins and nutrients, and grown around a tube-shaped mesh structure, causing the cells to form into the shape of a blood vessel. The researchers also discovered that pumping nutrients through the tube as it grows, in a rhythm that mimics the pulsing of a heart, helps to strengthen the vessel.

 

All in all, the growth process takes several months. Scientists are able to use a patient's own cells to make a personalized blood vessel, but doing so isn't cost-effective, and it often takes too long to actually be helpful to the patient. So as a last step, the cell tissue is bathed in a special solution that turns the cell structure into a structure of collagen, a type of protein group found in mammals' connective tissue.

 

 In the recent operation, the bioengineered blood vessel was implanted as part of a hemodialysis, the process of flushing toxins out of the body when the kidneys are unable to do so.

 

During hemodialysis, doctors often try to speed up a patient's blood flow by connecting an artery to a vein. Current methods for doing this involve grafting the blood vessels with a synthetic tube, which often leads to clotting, or surgically extracting blood vessels from elsewhere in the patient's body to form the connection, which opens up the risk of infection.

 

 Jeffrey Lawson, a vascular biologist at Duke University who helped develop the bioengineered vessel and also assisted in performing the surgical procedure, is confident that this breakthrough will help pave the way for bioengineering more complex organs.

 

"We hope this sets the groundwork for how [organs] can be grown, how they can incorporate into the host and how they can avoid being rejected immunologically," Lawson said in a statement.

 

"We start with [a blood vessel], and one day we may be able to engineer a liver or a kidney or an eye."

 

Sources - http://www.prothom-alo.com/detail/date/2013-06-13/news/360078

- http://www.prothom-alo.com/detail/date/2013-06-13/news/360078

- http://www.bizjournals.com/triangle/news/2013/06/07/duke-milestone-bioengineered-blood.html?ana=e_du_pap&s=article_du&ed=2013-06-07&u=tXWD5deyZ4nAjaYlVmk0OvqkJCM&t=1370632689

- http://www.renalbusiness.com/news/2013/06/duke-university-hospital-surgeons--implant-bioengineered-vein.aspx