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Sparfloxacin is used to treat various types of bacterial infections. Sparfloxacin may also be used for purposes other than those listed in this medication guide. Pharmacology: Interferes with microbial DNA synthesis. Indication: Treatment of community acquired pneumonia or bacterial exacerbation of chronic bronchitis caused by susceptible organisms. 

Sparfloxacin is a synthetic fluoroquinolone broad-spectrum antimicrobial agent in the same class as ofloxacin and norfloxacin. Sparfloxacin has in vitro activity against a wide range of gram-negative and gram-positive microorganisms. Sparfloxacin exerts its antibacterial activity by inhibiting DNA gyrase, a bacterial topoisomerase. DNA gyrase is an essential enzyme which controls DNA topology and assists in DNA replication, repair, deactivation, and transcription. Quinolones differ in chemical structure and mode of action from (beta)-lactam antibiotics. 

Quinolones may, therefore, be active against bacteria resistant to (beta)-lactam antibiotics. Although cross-resistance has been observed between Sparfloxacin and other fluoroquinolones, some microorganisms resistant to other fluoroquinolones may be susceptible to sparfloxacin. In vitro tests show that the combination of Sparfloxacin and rifampin is antagonistic against Staphylococcus aureus.

 Oral community-acquired pneumonia, Acute bacterial exacerbation of chronic bronchitis Adult: 100-300 mg daily, as a single dose or 2 divided doses. Renal impairment: Dosage adjustment may be necessary in severe impairment. 

Oral Community-acquired pneumonia, Acute bacterial exacerbation of chronic bronchitis Adult: 100-300 mg daily, as a single dose or 2 divided doses. Renal impairment: Dosage adjustment may be necessary in severe impairment. Special Populations: Renal impairment: Maintenance: 200 mg every other day. Indications: Adult: PO Acute bacterial exacerbation of chronic bronchitis ; Community-acquired pneumonia 100-300 mg/day in 1-2 divided doses. 

Indications: Gram positive bacteria (especially Strep. pneumoniae, Staphylococcus, Enterococcus), Bacteroides fragilis, other anaerobes and mycobacteria. Pneumonia, exacerbations of chronic bronchitis. Sinusitis and other ENT infections. Tuberculosis. MAC infection in AIDS patients. 

Pack Size 10 pcs