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Indication: Management of type 2 diabetes mellitus.

Dosage & Administration: Adults : Starting dose of Comet® (metformin hydrochloride tablet/oral solution) is 500 mg twice a day or 850 mg once a day, given with meals. Dosage increases should be made in increments of 500 mg weekly or 850 mg every 2 weeks, up to a total of 2000 mg per day, given in divided doses. Starting dose of Comet XR® (metformin hydrochloride extended release tablet) is 500 mg once daily with the evening meal. Dosage increases should be made in increments of 500 mg weekly, up to a maximum of 2000 mg once daily with the evening meal. If glycemic control is not achieved on Comet XR® 2000 mg once daily, a trial of Comet XR® 1000 mg twice daily should be considered. Pediatrics : Starting dose of Comet® is 500 mg twice a day, given with meals. Dosage increases should be made in increments of 500 mg weekly up to a maximum of 2000 mg per day, given in divided doses.

Preparation:  Comet XR^® 500 : Box containing 5 x 10 tablets in blister pack.